Epigenetics Compound Library

カタログ番号 L1200

ライブラリー構成化合物リスト Excel SDF

Epigenetics is the study of molecular processes that influence the flow of information between a constant DNA sequence and variable gene expression patterns. This includes investigation of nuclear organization, DNA methylation, histone modification and RNA transcription. Epigenetic processes can result in intergenerational (heritable) effects as well as clonal propagation of cell identity without any mutational change in DNA sequence. Epigenetics has the potential to be a key element in a paradigm change of our understanding of aging, development, cancer, heart disease, psychological disorders, and other diseases. For example, Epigenetic modifications have a considerable effect on cancer. Changes in the pattern of histone modifications in the promoter sequences as epigenetic regulation lead to changes in chromatin structure thus may be the cause of altered gene expression by activation of oncogenes.

The Epigenetics Compound Library by TargetMol, containing 960 compounds related to epigenetic regulation, can be used for research in epigenetics, high throughput screening and high content screening for new drugs in epigenetic modification.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。また、個人の方への販売は行っておりません。

パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

お問い合わせはこちら

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]

ライブラリ構成化合物リストを依頼する

製品概要

エピジェネティクスに関連する960種類の化合物を独自に厳選したライブラリーで、新薬探索のハイスループットスクリーニング（HTS）およびハイコンテンツスクリーニング（HCS）に最適
ターゲットにはHDAC、SIRT、HAT、HMTなど
化合物の概要、化学構造、標的、生物活性、IC50など詳細な情報を提供
構造的多様性、薬効、細胞膜透過性を有する化合物
NMRとHPLCなどの品質管理により適正な構造と高純度を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
ブルーアイス同梱にて出荷

サポートファイル

ライブラリーの取扱説明書 (635 KB) TargetMol のライブラリーカタログ (13.2 MB) ExcelおよびSDFファイル形式でのライブラリー構成化合物リストの要求

Publications Cited TargetMol Libraries

1. Neuro-oncology. 2023: noad222. 2. Protein & Cell. 2022. 3. Science Advances. 2022, 8(31): eabm3976. 4. Cancer Research. 2024. 5. Theranostics. 2021, 11(5): 2058.. 6. Oncoimmunology. 2022, 11(1): 2016158. 7. Stem Cells Translational Medicine. 2022. 8. Acta Pharmacologica Sinica. 2021: 1-13. 9. Frontiers in Oncology. 2022, 12: 870229..

もっと見る隠し

ライブラリーの構成

Apoptosis (156)

Epigenetic Reader Domain (144)

Histone Methyltransferase (117)

HDAC (111)

Autophagy (100)

JAK (98)

PKC (78)

AMPK (77)

PARP (75)

Sirtuin (58)

Aurora Kinase (53)

HIF/HIF Prolyl-Hydroxylase (49)

HIF (36)

Histone Demethylase (36)

Histone Acetyltransferase (29)

Tyrosine Kinases (27)

CDK (27)

Endogenous Metabolite (25)

FLT (24)

Antibacterial (23)

DNA Methyltransferase (23)

Pim (21)

STAT (20)

HIV Protease (18)

Influenza Virus (16)

PKA (16)

Akt (16)

VEGFR (15)

Mitophagy (15)

Src (15)

Antibiotic (14)

Parasite (13)

Caspase (13)

EGFR (13)

ERK (12)

Wnt/beta-catenin (12)

FGFR (10)

NF-κB (10)

COX (10)

PDGFR (10)

BCL (10)

Reactive Oxygen Species (10)

PPAR (9)

Bcr-Abl (9)

Virus Protease (9)

p38 MAPK (9)

Topoisomerase (8)

c-RET (8)

ROCK (8)

Syk (8)

P450 (7)

PAD (7)

DNA/RNA Synthesis (7)

TNF (7)

MEK (7)

Casein Kinase (7)

PI3K (7)

GSK-3 (7)

IL Receptor (6)

PLK (6)

JNK (6)

Nrf2 (6)

Antifungal (6)

Adenosine Receptor (5)

AChR (5)

PDE (5)

Ferroptosis (5)

Methionine Adenosyltransferase (MAT) (5)

Calcium Channel (5)

Dehydrogenase (5)

S6 Kinase (5)

CaMK (5)

Serine/threonin kinase (5)

HSV (4)

NO Synthase (4)

MAO (4)

IκB/IKK (4)

Chk (4)

p53 (4)

Monoamine Oxidase (3)

IGF-1R (3)

c-Fms (3)

MAPK (3)

HER (3)

MMP (3)

mTOR (3)

GABA Receptor (3)

HBV (3)

DYRK (3)

IFNAR (3)

Trk receptor (3)

RAAS (3)

Histamine Receptor (3)

Nucleoside Antimetabolite/Analog (3)

Potassium Channel (3)

BTK (3)

SGK (3)

Ligand for E3 Ligase (2)

cholecystokinin (2)

MLK (2)

Hippo pathway (2)

ATP Citrate Lyase (2)

TLR (2)

PROTACs (2)

Phosphatase (2)

Sodium Channel (2)

AChE (2)

TGF-beta/Smad (2)

Serine Protease (2)

Antiviral (2)

YAP (2)

Anti-infection (2)

Dopamine Receptor (2)

Carboxypeptidase (2)

DNA Alkylation (2)

Tyrosinase (2)

Ligands for Target Protein for PROTAC (2)

transporter (2)

LDL (2)

Gamma-secretase (2)

5-HT Receptor (2)

Fatty Acid Synthase (2)

Integrin (2)

Microtubule Associated (2)

Myosin (2)

HCV Protease (2)

DUB (2)

Indoleamine 2,3-Dioxygenase (IDO) (2)

c-Kit (2)

Proteasome (1)

ribosome (1)

Phospholipase (1)

Cannabinoid Receptor (1)

DAPK (1)

NADPH-oxidase (1)

NOD (1)

BMI-1 (1)

TAM Receptor (1)

CFTR (1)

PD-1/PD-L1 (1)

Reverse Transcriptase (1)

PTEN (1)

Beta Amyloid (1)

NADPH (1)

SIK (1)

IAP (1)

Adrenergic Receptor (1)

Glucokinase (1)

Antifolate (1)

Estrogen Receptor/ERR (1)

c-Myc (1)

Tie-2 (1)

PERK (1)

BACE (1)

UGT (1)

Antioxidant (1)

c-Met/HGFR (1)

Estrogen/progestogen Receptor (1)

DNA-PK (1)

NPC1L1 (1)

Transferase (1)

Carbonic Anhydrase (1)

NOS (1)

Proton pump (1)

Chloride channel (1)

E1/E2/E3 Enzyme (1)

GRK (1)

GST (1)

Lipoxygenase (1)

Free radical scavengers (1)

LRRK2 (1)

SARS-CoV (1)

HSP (1)

P-gp (1)

Beta-Secretase (1)

SGLT (1)

Telomerase (1)

Interleukin (1)

Androgen Receptor (1)

GluR (1)

Raf (1)

Mdm2 (1)

CCR (1)

Hedgehog/Smoothened (1)

Guanylate cyclase (1)

ROS (1)

Antifection (1)

Mitochondrial Metabolism (1)

DNA gyrase (1)

NMDAR (1)

P2X Receptor (1)

S1P Receptor (1)

化合物ライブラリー情報実例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty