TGF-beta/Smad Compound Library

カタログ番号 L4100

ライブラリー構成化合物リスト Excel SDF

Members of the transforming growth factor-β (TGF-β) family control growth, differentiation and apoptosis of cells, and have important functions during embryonic development. There are three known isoforms of TGF-β (TGF-β1, TGF-β2 and TGF-β3) expressed in mammalian tissues. TGF-β isoforms signal through three surface receptors, known as the TGF-β type I, type II, and type III receptors (TβRI, TβRII, and TβRIII, respectively) which are expressed on the surface of many cell types such as fibroblasts, lymphocytes, and hemopoietic cells, etc. The binding of TGF-β and receptors transduces the signals by phosphorylating carboxy-terminal serine residues of receptor-regulated (R-) Smads. The activated R-Smads form hetero-oligomeric complexes with a common-partner (co-) Smad, that is, Smad4 in vertebrate cells. The complexes translocate into the nucleus where they regulate the expression of target genes.

TGF-beta/Smad Compound Library from TargetMol, a unique collection of 185 TGF-beta/Smad signaling targeted compounds, can be used for research in TGF-beta/Smad signaling and related drug screening (high throughput and high content screening).

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パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

お問い合わせはこちら

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]

ライブラリ構成化合物リストを依頼する

製品概要

TGF-beta/Smadシグナル伝達をターゲットとする185化合物を収集した独自のライブラリーで、ハイスループットスクリーニング（HTS）およびハイコンテンツスクリーニング（HCS）に最適
非臨床試験および臨床試験において生物活性と安全性が確認済
化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
構造的多様性、薬効、細胞膜透過性を有する化合物
NMRとHPLCにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
ブルーアイス同梱にて出荷

サポートファイル

ライブラリーの取扱説明書 (635 KB) TargetMol のライブラリーカタログ (13.2 MB) ExcelおよびSDFファイル形式でのライブラリー構成化合物リストの要求

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

もっと見る隠し

ライブラリーの構成

PKC (77)

TGF-beta/Smad (59)

ROCK (44)

Apoptosis (22)

ALK (19)

Autophagy (18)

PKA (16)

CDK (8)

ERK (8)

Antibacterial (7)

Akt (6)

Src (6)

Endogenous Metabolite (5)

S6 Kinase (5)

Serine/threonin kinase (5)

PDGFR (4)

Casein Kinase (4)

Calcium Channel (4)

CaMK (4)

VEGFR (4)

SGK (4)

Parasite (4)

DNA/RNA Synthesis (4)

BCL (3)

AMPK (3)

NF-κB (3)

Influenza Virus (3)

EGFR (3)

Antifungal (3)

p38 MAPK (3)

GSK-3 (2)

IGF-1R (2)

Antibiotic (2)

COX (2)

HIV Protease (2)

FGFR (2)

Sodium Channel (2)

Phosphatase (2)

MEK (2)

MAPK (2)

GRK (2)

Syk (2)

LDL (2)

FLT (2)

Tyrosine Kinases (2)

Wnt/beta-catenin (2)

Myosin (2)

5-HT Receptor (2)

Rho (2)

MLK (2)

p53 (1)

Ras (1)

Antiviral (1)

LRRK2 (1)

Trk receptor (1)

PAI-1 (1)

TAM Receptor (1)

STAT (1)

ATPase (1)

Reactive Oxygen Species (1)

mTOR (1)

Caspase (1)

Proton pump (1)

NOS (1)

YAP (1)

PI3K (1)

c-Met/HGFR (1)

RAAS (1)

JNK (1)

Virus Protease (1)

Estrogen Receptor/ERR (1)

PARP (1)

Serine Protease (1)

Nucleoside Antimetabolite/Analog (1)

Topoisomerase (1)

Aurora Kinase (1)

RIP kinase (1)

UGT (1)

Bcr-Abl (1)

AAK1 (AP2 associated kinase 1) (1)

BTK (1)

Antifection (1)

Opioid Receptor (1)

DNA Alkylation (1)

JAK (1)

HSV (1)

CCR (1)

Chk (1)

S1P Receptor (1)

化合物ライブラリー情報実例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty