Anti-Neurodegenerative Disease Compound Library

カタログ番号 L2620

ライブラリー構成化合物リスト Excel SDF

Neurodegenerative disorders, such as Alzheimer’s disease (AD), Parkinson’s disease (PD), Huntington’s disease (HD), spinal muscular atrophy (SMA), and amyotrophic lateral sclerosis (ALS), are incurable and debilitating conditions characterized by progressive degeneration of speciﬁc neurons within the brains of aﬀected individuals. Neurodegenerative diseases have become an enormous economic burden that is projected to grow signiﬁcantly over the next few decades in the absence of any new therapeutic interventions.

Drugs for the central nervous system, including neurodegenerative diseases, that entered clinical development, have a considerably lower probability of reaching the marketplace (7%) than the industry average across other therapeutic areas (15%), and require a longer time for development and regulatory approval (average of 12.6 years) compared with most other diseases (e.g., 6.3 years for cardiovascular and 7.5 years for gastrointestinal indications).

In this compound library, TargetMol collects 2154 compounds related to neurodegenerative diseases having therapeutic effect or acting on neurodegenerative disease-related targets.

TargetMolの製品は全て研究用試薬です。人体にはご使用できません。また、個人の方への販売は行っておりません。

パッケージサイズ
1 mg
30 μL * 10 mM (in DMSO)
50 μL * 10 mM (in DMSO)
100 μL * 10 mM (in DMSO)
250 μL * 10 mM (in DMSO)

お問い合わせはこちら

If the above compound libraries do not match your needs,
please contact our compound library specialist for a customized compound library at [email protected]

ライブラリ構成化合物リストを依頼する

製品概要

神経変性疾患に関連する2154種類の化合物を独自にコレクション
ハイスループットスクリーニング(HTS)およびハイコンテンツスクリーニング(HCS)に最適
ターゲットとしてAchE、NMDA、CGRP、β-セクレターゼ、γ-セクレターゼ、ドーパミン受容体、アデノシン受容体、5-HT受容体などをカバー
一部にFDA承認薬を含む
化合物の概要、化学構造、標的、IC50値、生物活性など詳細な情報を提供
NMRとHPLC/LCMSにより高純度と高品質を担保

ライブラリーのカスタマイズ

TargetMol社化合物ライブラリーは自由にカスタマイズできます! もっと詳しく

梱包・保管

バーコード付き貯蔵管や96/384-wellプレートに入っている粉末固体またはDMSO溶液
ブルーアイス同梱にて出荷

サポートファイル

ライブラリーの取扱説明書 (635 KB) TargetMol のライブラリーカタログ (13.2 MB) ExcelおよびSDFファイル形式でのライブラリー構成化合物リストの要求

Publications Cited TargetMol Libraries

1. Cell Stem Cell. 2022 Apr 29(4) 545–558. 2. Science Bulletin. 2022. 3. Science Translational Medicine. 2022, 14(656): eabn3231. 4. Science Advances. 2023, 9(9): eade3760. 5. Nature. 2020, 582: 289-293. 6. Nature Biotechnology. 2021, 39(11): 1444-1452. 7. Nature Communications. 2022, 13(1): 1-15.. 8. Nature Communications. 2023, 14(1): 1020.. 9. Nature Communications. 2023, 14(1): 2756..

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ライブラリーの構成

5-HT Receptor (292)

AChR (280)

Dopamine Receptor (234)

Adrenergic Receptor (206)

GABA Receptor (142)

Apoptosis (138)

GluR (127)

Autophagy (127)

AChE (95)

Opioid Receptor (95)

Histamine Receptor (93)

Endogenous Metabolite (89)

NMDAR (83)

PDE (74)

iGluR (70)

Beta Amyloid (66)

COX (64)

MAO (57)

Monoamine Oxidase (44)

Gamma-secretase (44)

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Serotonin Transporter (39)

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Reactive Oxygen Species (37)

NF-κB (36)

PPAR (35)

Norepinephrine (34)

Potassium Channel (33)

Adenosine Receptor (33)

GSK-3 (33)

Caspase (28)

Sodium Channel (28)

Calcium Channel (26)

P450 (26)

Parasite (23)

Influenza Virus (20)

HIV Protease (19)

CaMK (18)

Nrf2 (18)

TNF (18)

LRRK2 (17)

BACE (16)

Mitophagy (15)

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ERK (14)

Ferroptosis (13)

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Beta-Secretase (12)

Mitochondrial Metabolism (12)

Cannabinoid Receptor (11)

TRP/TRPV Channel (11)

Antibiotic (11)

IL Receptor (11)

Dehydrogenase (11)

Akt (10)

Bcr-Abl (10)

Transferase (10)

Src (9)

NO Synthase (9)

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Imidazoline Receptor (8)

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Sigma receptor (7)

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OX Receptor (7)

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HDAC (6)

Aurora Kinase (6)

Lipoxygenase (6)

c-Kit (6)

PKC (6)

AMPK (6)

VEGFR (6)

Wnt/beta-catenin (6)

MRP (6)

Sirtuin (6)

P2X Receptor (6)

MEK (6)

MT Receptor (6)

EGFR (5)

SARS-CoV (5)

S1P Receptor (5)

FAAH (5)

AAK1 (AP2 associated kinase 1) (5)

P2Y Receptor (5)

Melatonin Receptor (5)

LPL Receptor (5)

PKA (5)

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Histone Methyltransferase (4)

Trk receptor (4)

Prostaglandin Receptor (4)

Retinoid Receptor (4)

RAAS (4)

mTOR (4)

IGF-1R (4)

ABC (4)

FGFR (4)

CCR (4)

HSV (4)

Neurokinin receptor (4)

Epigenetic Reader Domain (4)

ROR (4)

NOS (4)

HMG-CoA Reductase (4)

JAK (4)

Carbonic Anhydrase (4)

Tyrosinase (4)

Anti-infection (4)

NADPH (3)

Histone Acetyltransferase (3)

Estrogen Receptor/ERR (3)

Rho (3)

MAPK (3)

Casein Kinase (3)

TGF-beta/Smad (3)

HIF/HIF Prolyl-Hydroxylase (3)

Histone Demethylase (3)

c-Fms (3)

p53 (3)

NOD (3)

Glucosidase (3)

HER (3)

Glucocorticoid Receptor (3)

Epoxide Hydrolase (3)

S6 Kinase (3)

Amino Acids and Derivatives (3)

c-Met/HGFR (2)

NOD-like Receptor (NLR) (2)

Free radical scavengers (2)

Gap Junction Protein (2)

Raf (2)

Decarboxylase (2)

FAK (2)

Integrin (2)

IFNAR (2)

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RSV (2)

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STAT (2)

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GPR (2)

CRISPR/Cas9 (2)

Transaminase (2)

Progesterone Receptor (2)

transporter (2)

CSF-1R (2)

Monoamine Transporter (2)

FXR (2)

advanced glycation end products (2)

Immunology/Inflammation related (2)

Aryl Hydrocarbon Receptor (2)

UGT (2)

Cysteine Protease (2)

Stearoyl-CoA Desaturase (SCD) (2)

Guanylate cyclase (2)

PAFR (2)

PGE Synthase (2)

Antifection (2)

BTK (2)

Antiviral (2)

HBV (2)

STING (2)

Topoisomerase (2)

Annexin A (1)

Monocarboxylate transporter (1)

HCV Protease (1)

Somatostatin (1)

NMU2R (1)

Syk (1)

PDGFR (1)

Bombesin Receptor (1)

E1/E2/E3 Enzyme (1)

DNA Methyltransferase (1)

DNA Alkylation (1)

IRAK (1)

PAK (1)

Neuropeptide Y Receptor (1)

NPC1L1 (1)

Adiponectin receptor (1)

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LDL (1)

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GRK (1)

SGK (1)

TLR (1)

Chk (1)

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HSP (1)

OCT (1)

OAT (1)

Acyltransferase (1)

GluCls (1)

PAI-1 (1)

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Hck (1)

Serine/threonin kinase (1)

GTPase (1)

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GST (1)

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Telomerase (1)

PAD (1)

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HIF (1)

Adenosine deaminase (1)

Na+/Ca2+ Exchanger (1)

Hydroxylase (1)

Arrestin (1)

RAR/RXR (1)

Nucleoside Antimetabolite/Analog (1)

PDK (1)

RANKL/RANK (1)

DUB (1)

Indoleamine 2,3-Dioxygenase (IDO) (1)

Aromatase (1)

Androgen Receptor (1)

Proteasome (1)

化合物ライブラリー情報実例

Empty	1000025-07-9	1000413-72-8	229005-80-5	1000787-75-6	946387-07-1	1000998-59-3	1175526-27-8	1001288-58-9	1001350-96-4	1001404-83-6	Empty
Empty	Vadadustat	TAK875	TAK-779	Tegobuvir	RN-1734	BMS-687453	AM211	FT011	BMS754807	AAI101	Empty
Empty	1001625-82-6	1001645-58-4	1001753-24-7	1001908-89-9	1002304-34-8	1002-84-2	100291-86-9	100299-08-9	10030-52-1	10040-45-6	Empty
Empty	RPW-24	SRT1720 hydrochloride	INH6	SRT 2183	AMG208	Pentadecanoic acid	Apiopaeonoside	Pemirolast potassium	L-Anserine nitrate salt	Sodium Picosulfate	Empty
Empty	100427-26-7	1004316-88-4	10045-45-1	100462-37-1	1004990-28-6	100-51-6	1005-24-9	1005264-47-0	1005334-57-5	1005342-46-0	Empty
Empty	Lercanidipine	Cobicistat	1-Ethyl-2-benzimidazolinone	ROSIRIDIN	PF-AKT400	Benzyl alcohol	1-Methylnicotinamide chloride	MX69	CVT-10216	LCL161	Empty
Empty	1005491-05-3	100-55-0	1005504-62-0	1005883-72-6	100643-71-8	1007207-67-1	10075-50-0	1007647-73-5	100784-20-1	10083-24-6	Empty
Empty	Tirasemtiv	Roniacol	Rg3039	Z433927330	Desloratadine	CH5132799	5-Bromoindole	Smurf1-IN-A01	Halosulfuron-methyl	Piceatannol	Empty
Empty	100872-83-1	100874-08-6	1009119-64-5	1009119-65-6	100929-71-3	1009298-09-2	1009298-59-2	100929-99-5	1009734-33-1	10097-84-4	Empty
Empty	ML346	SB 4	Daclatasvir	Daclatasvir dihydrochloride	NADPH (tetracyclohexanamine)	AZD8055	Vistusertib	PAβN dihydrochloride	HZ1157	Rotundine	Empty
Empty	1009816-48-1	1009817-63-3	1009820-21-6	100986-85-4	101001-34-7	1010411-21-8	1010-60-2	1011244-68-0	1011301-27-1	1011529-10-4	Empty
Empty	Thiamet G	B-AP15	Silmitasertib	Levofloxacin	Pamicogrel	GSK369796 Dihydrochloride	2-Chloronaphthoquinone	TFAP	Tenovin3	Azvudine	Empty
Empty	101152-94-7	101155-02-6	1011557-82-6	1011-74-1	101-20-2	1012054-59-9	101-21-3	101-26-8	101303-98-4	1013101-36-4	Empty
Empty	Milnacipran hydrochloride	BW-A78U	Tenovin-6	DL-Normetanephrine hydrochloride	Triclocarban	CUDC101	Chlorpropham	Mestinon	Zacopride hydrochloride	PF04691502	Empty
Empty	101-31-5	1013-69-0	1013750-77-0	1013753-99-5	10138-52-0	1013920-15-4	1013937-63-7	1014691-61-2	101477-54-7	101494-95-5	Empty
Empty	L-Hyoscyamine	Noreugenin	ML-030	BC-1382	Gadolinium chloride	Vorolanib	VTP-27999 TFA	GSK0660	Lomerizine hydrochloride	8-CHLOROQUINAZOLIN-4(1H)-ONE	Empty