Lipid Metabolism Compound Library

Lipids are fatty acids and their derivatives, and substances related biosynthetically or functionally to these compounds. Lipids are commonly subdivided into four main groups: fatty acids (saturated and unsaturated), glycerides (glycerol-containing lipids), nonglyceride lipids (sphingolipids, steroids, waxes), and complex lipids (lipoproteins). Like the other large biological molecules, lipids perform many different functions in a cell. Lipids are critical for cell structure, function, and energy, as well as organs and body insulation and protection. Lipid metabolism is the synthesis and degradation of lipids in cells, involving the breakdown or storage of fats for energy and the synthesis of structural and functional lipids, such as those involved in the construction of cell membranes. Lipids metabolites are extremely essential for a wide range of cellular communication and metabolism. 

Numerous studies have shown that lipid metabolism plays an important role in the pathogenesis of a wide range of chronic diseases such as cardiovascular disease, aging, and cancer, etc. Lipid metabolism has now been accepted as a major metabolic pathway that is involved in many aspects of cancer cell biology. Discovering novel mechanisms of the lipid role in diseases and new ways to exploit these mechanisms for the optimal drug design would be beneficial for the prevention and treatment of these diseases.

TargetMol’s Lipid Metabolism Compound Library collects 496 compounds acting on key targets related to lipid metabolism, such as Acetyl-CoA Carboxylase、Acyltransferase、cholesteryl ester transfer protein (CETP)、FAAH、Fatty Acid Synthase (FASN)、HMG-CoA Reductase (HMGCR), etc. It is a powerful tool that can be used in lipid metabolism related drug development and mechanism studies.