Methylation Compound Library

Methylation is an important way of protein and nucleic acid modification that regulates gene expression and is closely related to many diseases such as cancer, aging, and Alzheimer's disease. It is an important field of study in epigenetics. The most common methylation modifications are DNA methylation and histone methylation

DNA methylation, the addition of methyl groups to DNA, was one of the first methylation modifications discovered. The modification occurs specifically at the CpG site, where cytosine is attached to guanylate via phosphate. Numerous studies have shown that DNA methylation can cause changes in chromatin structure, DNA conformation, DNA stability and the way DNA interacts with proteins, thereby controlling gene expression.

Histone methylation refers to the methylation that occurs at the N-terminal arginine Arg(R) or lysine Lys(K) residues of H3 and H4 histones and is mediated and catalyzed by histone methyltransferases. Histone methylation mainly causes heterochromatin formation, gene imprinting, X chromosome inactivation and transcriptional regulation.

TargetMol Methylation Compound Library is a collection of 131 methylation-related compounds that can be used for research in epigenetics, differentiation, aging, cancer, and more.