keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 7,500 | |||
5 mg | 在庫あり | ¥ 16,000 | |||
10 mg | 在庫あり | ¥ 23,000 | |||
25 mg | 在庫あり | ¥ 37,500 | |||
50 mg | 在庫あり | ¥ 55,000 | |||
100 mg | 在庫あり | ¥ 81,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 20,000 |
説明 | (R)-CR8 trihydrochloride (CR8, (R)-Isomer trihydrochloride) is a CDK1/2/5/7/9 inhibitor that acts as a molecular glue degrader with neuroprotective activity and induces apoptosis. |
ターゲット&IC50 | CK1δ/ε:0.4 μM, CDK9-CyclinT1:0.18 μM, CDK2-CyclinE:0.041 μM, CDK1:0.09 μM, CDK5-p25:0.11 μM, CDK7-CyclinH:1.1 μM, CDK2:0.072 μM |
In vitro | In the SH-SY5Y cell line, (R)-CR8 trihydrochloride (0.1, 1, 10, 100 μM; 24 hours) reduced cell survival in a dose-dependent manner[1]. |
In vivo | In 10 to 12-week-old male Sprague-Dawley rats (310 to 330 g), administration of (R)-CR8 trihydrochloride at 5 mg/kg (i.p.) resulted in a significant reduction in lesion size[2]. |
別名 | CR8, (R)-Isomer trihydrochloride |
分子量 | 540.92 |
分子式 | C24H32Cl3N7O |
CAS No. | 1786438-30-9 |
keep away from moisture
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (55.46 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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(R)-CR8 trihydrochloride 1786438-30-9 Apoptosis Cell Cycle/Checkpoint CDK (R)-CR-8 trihydrochloride (R)CR8 trihydrochloride CR-8 Trihydrochloride CR 8 (R) CR8 trihydrochloride CR8, (R)-Isomer trihydrochloride CR8, Isomer (R)-CR8 trihydrochloride CR 8 Trihydrochloride CR8 CR8 Trihydrochloride CR8, Isomer Trihydrochloride CR-8 Inhibitor inhibitor inhibit