Powder: -20°C for 3 years | In solvent: -80°C for 1 year
γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist.
説明 | γ-Linolenic Acid methyl ester (Methyl gamma-linolenate) is a weak leukotriene B4 (LTB4) receptor antagonist. |
ターゲット&IC50 | LTB4:1 μM (ki; GLA) |
In vitro | γ-Linolenic acid methyl ester is an esterified version of the free acid which is less water soluble but more amenable for the formulation of GLA-containing diets and dietary supplements. GLA was identified as an ω-6 fatty acid which could be elongated to arachidonic acid for endogenous eicosanoid synthesis. GLA was found to be a weak leukotriene B4 (LTB4) receptor antagonist, which was able to inhibit [3H]-LTB4 binding to porcine neutrophil membranes with a Ki of 1 μM |
In vivo | In an in-vivo model of LTB4-induced bronchoconstriction, γ-Linolenic acid methyl ester at a 1 mg/kg i.v. dose could result in 53% inhibition, indicating that essential fatty acids are LTB4 receptor antagonists, which may account in part for reported anti-inflammatory activities. |
別名 | Methyl gamma-linolenate |
分子量 | 292.46 |
分子式 | C19H32O2 |
CAS No. | 16326-32-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
dimethyl formamide: 100mg/ml (341.88 mM)
DMSO: 100mg/ml (341.88 mM)
You can also refer to dose conversion for different animals. 詳細
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γ-Linolenic Acid methyl ester 16326-32-2 Immunology/Inflammation LTR γ Linolenic Acid methyl ester r-Linolenic Acid methyl ester gamma-Linolenic Acid methyl ester Methyl gamma-linolenate γLinolenic Acid methyl ester Inhibitor inhibitor inhibit