Powder: -20°C for 3 years | In solvent: -80°C for 1 year
ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in melanoma cell lines, exhibiting antitumor activity in vitro[1][2].
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 27,500 | |||
5 mg | 在庫あり | ¥ 68,500 | |||
10 mg | 在庫あり | ¥ 108,500 | |||
25 mg | 在庫あり | ¥ 178,500 | |||
50 mg | 在庫あり | ¥ 250,500 | |||
100 mg | 在庫あり | ¥ 335,000 | |||
500 mg | 在庫あり | ¥ 672,500 |
説明 | ζ-Stat (NSC37044), a specific and atypical inhibitor of PKC-ζ with an IC50 of 5 μM, demonstrates the ability to inhibit proliferation and induce apoptosis in melanoma cell lines, exhibiting antitumor activity in vitro[1][2]. |
ターゲット&IC50 | PKCζ:5 μM |
In vitro | ζ-Stat (0.1-20 μM) shows only 13% inhibition on PKC-Ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1].ζ-Stat (0.1-10 μM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1].ζ-Stat (7 or 10 μM; 24-72?h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2].ζ-Stat (5 μM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1].ζ-Stat (5 μM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1]. |
分子量 | 384.36 |
分子式 | C10H8O10S3 |
CAS No. | 3316-02-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 62.5 mg/mL (162.61 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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Ζ-Stat 3316-02-7 Chromatin/Epigenetic Cytoskeletal Signaling PKC antitumor NSC 37044 melanoma ζ-Stat NSC-37044 kinase NSC37044 Protein kinase C ΖStat atypical Inhibitor Apoptosis protein Ζ Stat inhibit PKC-ζ inhibitor