Powder: -20°C for 3 years | In solvent: -80°C for 1 year
360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 22,500 | |||
2 mg | 在庫あり | ¥ 35,500 | |||
5 mg | 在庫あり | ¥ 51,000 | |||
10 mg | 在庫あり | ¥ 77,500 | |||
25 mg | 在庫あり | ¥ 128,000 | |||
50 mg | 在庫あり | ¥ 180,500 | |||
100 mg | 在庫あり | ¥ 257,000 |
説明 | 360A is a stabilizing G-Quadruplex ligand, and also inhibits telomerase activity for telomerase in TRAP-G4 assay(IC50 : 300 nM). |
ターゲット&IC50 | Telomerase:300 nM |
In vitro | A549 lung carcinoma cell lines treatment with 5 μM of 360A led to an inhibition of cell proliferation within 11 days of treatmen. Treatment with the newly synthesized dimer (360A)2A led to a comparable antiproliferative effect[1] |
細胞研究 | Supplemented with 10% fetal calf serum (FCS) and 1% penicillin/streptomycin. A549 cells were maintained in humidified incubators at 37 °C in an atmosphere containing 5% CO2 and ambient oxygen of 20%. Cells were grown in 25 cm^2 flasks (150,000 cells/flask) and treated with 5 μM of 360A or (360A)2A every 3 or 4 days (i.e., at each reseeding) until cultures were terminated. Control cells were either non-treated or treated with 0.1% DMSO. At each reseeding the remaining cells were pelleted and snap frozen for further DNA extraction.Statistical analysis was performed using GraphPad Prism 5. A Chi-square test was used to compare TDEs frequencies[1]. |
分子量 | 449.5 |
分子式 | C27H23N5O2 |
CAS No. | 794458-56-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Slightly soluble
You can also refer to dose conversion for different animals. 詳細
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360A 794458-56-3 Cell Cycle/Checkpoint DNA Damage/DNA Repair DNA/RNA Synthesis Telomerase inhibit Inhibitor G-quadruplex inhibitor