Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AM-8735 is an inhibitor of MDM2 ( IC50: 25 nM).
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 418,000 |
50 mg | 約8-10 週間 | ¥ 546,500 |
100 mg | 約8-10 週間 | ¥ 711,500 |
ターゲット&IC50 | MDM2:25 nM |
In vivo | AM-8735 exhibits potent antitumor properties in the SJSA-1 osteosarcoma xenograft model, achieving an effective dose (ED50) of 41 mg/kg[1]. Additionally, AM-8735 significantly induces p21 mRNA expression in a time- and concentration-dependent manner within SJSA-1 osteosarcoma tumors, as demonstrated through in vivo pharmacodynamic assays. |
分子量 | 568.51 |
分子式 | C27H31Cl2NO6S |
CAS No. | 1429386-01-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AM-8735 1429386-01-5 Apoptosis Mdm2 AM8735 AM 8735 Inhibitor inhibitor inhibit