Powder: -20°C for 3 years | In solvent: -80°C for 1 year
AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 9,500 | |||
2 mg | 在庫あり | ¥ 13,000 | |||
5 mg | 在庫あり | ¥ 27,000 | |||
10 mg | 在庫あり | ¥ 45,000 | |||
25 mg | 在庫あり | ¥ 80,000 | |||
50 mg | 在庫あり | ¥ 116,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 30,000 |
説明 | AT13148 is an oral-active and ATP-competitive, multi-AGC kinase inhibitor for Akt1/2/3, p70S6K, PKA, and ROCKI/II. |
ターゲット&IC50 | ROCK1:6 nM, ROCK2:4 nM, p70 S6K:8 nM, PKA:3 nM, Akt1:38 nM |
キナーゼ試験 | In vitro kinase assays: AT13148 is assayed against 40 kinases and the percentage inhibition at 10 μM of AT13148 is determined. Individual IC50 values are measured for selected kinases using ATP concentrations equivalent to the Km for each enzyme. |
細胞研究 | Cytotoxicity is determined using a 72 h Alamar Blue assay or a 96 h SRB assay. (Only for Reference) |
分子量 | 313.78 |
分子式 | C17H16ClN3O |
CAS No. | 1056901-62-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 58 mg/mL (184.8 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
AT13148 1056901-62-2 Cell Cycle/Checkpoint Cytoskeletal Signaling MAPK Metabolism PI3K/Akt/mTOR signaling Stem Cells Tyrosine Kinase/Adaptors Akt PKA ROCK SGK S6 Kinase inhibit Protein kinase B S6K PKB AT-13148 ROK Protein kinase A Rho-associated protein kinase Rho-associated kinase Ribosomal S6 Kinase (RSK) Rho-kinase Inhibitor AT 13148 inhibitor