Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is the (S)-enantiomer of BAY-1143572. Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor, which inhibits CDK9 / CycT1 with an IC 50 of 16 nM.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 321,500 |
50 mg | 約6-8 週間 | ¥ 418,000 |
100 mg | 約6-8 週間 | ¥ 633,500 |
説明 | Atuveciclib S-Enantiomer (BAY-1143572 S-Enantiomer) is the (S)-enantiomer of BAY-1143572. Atuveciclib S-Enantiomer is a potent and selective CDK9 inhibitor, which inhibits CDK9 / CycT1 with an IC 50 of 16 nM. |
ターゲット&IC50 | CDK9-CyclinT1:16 nM |
In vitro | Atuveciclib (BAY-1143572) S-Enantiomer reveals very similar in vitro properties compared with Atuveciclib (BAY-1143572), well within the limits of measurement accuracy. However, with multiple batches of Atuveciclib (BAY-1143572) S-Enantiomer, there is a trend toward a slightly lower activity against CDK9 in the biochemical assay (IC 50 CDK9/CycT1: 16 nM) and antiproliferative activity against HeLa cells (IC 50 : 1100 nM) [1]. |
In vivo | Atuveciclib (BAY-1143572) S-Enantiomer exhibits blood/plasma ratios close to 1, suggesting a similarity in distribution. Compared to its parent compound, Atuveciclib (BAY-1143572), this enantiomer demonstrates comparable pharmacokinetic (PK) properties in rats, including a clearance rate (CL b) of 1.2 L/kg per hour, a steady-state volume of distribution (V ss) of 1.2 L/kg, a half-life (t 1/2) of 0.6 hours, and a bioavailability (F) of 53% [1]. |
別名 | BAY-1143572 S-Enantiomer |
分子量 | 387.43 |
分子式 | C18H18FN5O2S |
CAS No. | 2250279-81-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 113 mg/mL (291.67 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Atuveciclib S-Enantiomer 2250279-81-1 Cell Cycle/Checkpoint CDK BAY-1143572 S-Enantiomer Atuveciclib S Enantiomer Atuveciclib SEnantiomer Inhibitor inhibitor inhibit