Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a murine model of AAV.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | お問い合わせ | ¥ 14,500 |
2 mg | お問い合わせ | ¥ 21,000 |
5 mg | お問い合わせ | ¥ 34,000 |
10 mg | お問い合わせ | ¥ 54,000 |
25 mg | お問い合わせ | ¥ 108,000 |
50 mg | お問い合わせ | ¥ 154,500 |
1 mL * 10 mM (in DMSO) | お問い合わせ | ¥ 40,000 |
説明 | Avacopan (CCX168) is an orally administered small-molecule C5aR ( IC50 : 0.1 nM.)antagonist that blocks the effects of C5a and prevents the development of GN induced by anti-myeloperoxidase antibodies in a murine model of AAV. |
ターゲット&IC50 | C5aR:0.1 nM |
In vivo | CCX168 (avacopan), an orally administered selective and potent C5aR inhibitor.?CCX168 blocked the C5a binding, C5a-mediated migration, calcium mobilization, and CD11b upregulation in U937 cells as well as in freshly isolated human neutrophils.?CCX168 retains high potency when present in human blood.?A transgenic human C5aR knock-in mouse model allowed comparison of the in vitro and in vivo efficacy of the molecule.?CCX168 effectively blocked migration in in vitro and ex vivo chemotaxis assays, and it blocked the C5a-mediated neutrophil vascular endothelial margination.?CCX168 was effective in migration and neutrophil margination assays in cynomolgus monkeys[1]. |
別名 | CCX168 |
分子量 | 581.64 |
分子式 | C33H35F4N3O2 |
CAS No. | 1346623-17-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 10 mg/mL (17.19 mM)
You can also refer to dose conversion for different animals. 詳細
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Avacopan 1346623-17-3 Immunology/Inflammation Complement System CCX168 CCX-168 CCX 168 Inhibitor inhibitor inhibit