Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 約 35 days | ¥ 53,500 |
5 mg | 約 35 days | ¥ 171,000 |
10 mg | 約 35 days | ¥ 312,500 |
25 mg | 約 35 days | ¥ 652,000 |
説明 | Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor. |
In vitro | The compounds were docked into 5-HT1A, 5-HT2A, D1, D2, M1 receptors and acetylcholinesterase (AChE) using AutoDock and their central nervous system (CNS) drug-like properties were determined using Discovery Studio molecular properties and ADMET descriptors. The compounds were screened in vitro using radioligand receptor binding and AChE inhibition assays. In silico studies showed that the parent bacosides were not able to dock into the chosen CNS targets and had poor molecular properties as a CNS drug. In contrast, the aglycones and their derivatives showed better binding affinity and good CNS drug-like properties, were well absorbed through the intestines and had good blood brain barrier (BBB) penetration. Among the compounds tested in vitro, ebelin lactone showed binding affinity towards M1 (Ki = 0.45 μM) and 5-HT2A (4.21 μM) receptors. Bacoside A and Bacopaside X (9.06 μM) showed binding affinity towards the D1 receptor. |
植物由来 |
分子量 | 899.07 |
分子式 | C46H74O17 |
CAS No. | 94443-88-6 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Bacopaside X 94443-88-6 GPCR/G Protein Neuroscience Dopamine Receptor Inhibitor inhibitor inhibit