Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
1 mg | 在庫あり | ¥ 8,500 | |||
2 mg | 在庫あり | ¥ 12,000 | |||
5 mg | 在庫あり | ¥ 19,000 | |||
10 mg | 在庫あり | ¥ 29,000 | |||
25 mg | 在庫あり | ¥ 53,500 | |||
50 mg | 在庫あり | ¥ 90,000 | |||
100 mg | 在庫あり | ¥ 135,500 | |||
500 mg | 在庫あり | ¥ 294,000 |
説明 | Bimiralisib (PI3K-IN-2) is an orally bioavailable pan inhibitor of PI3K and inhibitor of the mTOR, with potential antineoplastic activity. PI3K-IN-2 inhibits the PI3K kinase isoforms alpha, beta, gamma and delta and, to a lesser extent, mTOR kinase, which may result in tumor cell apoptosis and growth inhibition in cells overexpressing PI3K/mTOR. Activation of the PI3K/mTOR pathway promotes cell growth, survival, and resistance to both chemotherapy and radiotherapy. |
ターゲット&IC50 | mTOR:12 nM(Kd), PI3Kγ:25 nM(Kd), PI3Kα:1.5 nM(Kd), PI3Kβ:11 nM(Kd), PI3Kδ:25 nM(Kd) |
別名 | 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine, PQR309, PI3K-IN-2 |
分子量 | 411.38 |
分子式 | C17H20F3N7O2 |
CAS No. | 1225037-39-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (12.15 mM)
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Bimiralisib 1225037-39-7 MAPK Others PI3K/Akt/mTOR signaling mTOR S6 Kinase PI3K inhibit Inhibitor PQR-309 5-(4,6-dimorpholino-1,3,5-triazin-2-yl)-4-(trifluoromethyl)pyridin-2-amine PQR 309 Phosphoinositide 3-kinase PQR309 PI3K-IN-2 Mammalian target of Rapamycin inhibitor