Powder: -20°C for 3 years | In solvent: -80°C for 1 year
(±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells.
説明 | (±)-Boehmenan shows potent protein-tyrosine phosphatase 1B (PTP1B) inhibitory activity in vitro with the IC(50) values of 43.5 uM, it inhibits PTP1B activity in a competitive manner. Boehmenan exhibits the potent cytotoxic effects against many cancer cell lines, boehmenan-mediated anti-tumor property is mediated by modulation of mitochondria and EGFR signaling pathway in A549 NSCLC cells. |
植物由来 |
分子量 | 712.74 |
分子式 | C40H40O12 |
CAS No. | 57296-22-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Boehmenan 57296-22-7 Angiogenesis Apoptosis Chromatin/Epigenetic Cytoskeletal Signaling DNA Damage/DNA Repair JAK/STAT signaling MAPK Metabolism PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors PARP ERK EGFR Phosphatase MEK Akt Caspase Wnt/beta-catenin p53 STAT Inhibitor inhibitor inhibit