Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6.
パッケージサイズ | 在庫状況 | 単価(税別) | |
---|---|---|---|
5 mg | お問い合わせ | ¥ 167,000 | |
10 mg | お問い合わせ | ¥ 228,500 | |
50 mg | お問い合わせ | ¥ 503,000 | |
100 mg | お問い合わせ | お問い合わせ | |
200 mg | お問い合わせ | お問い合わせ | |
1 mL * 10 mM (in DMSO) | お問い合わせ | ¥ 242,500 |
説明 | CP-10 is a PROTAC with highly selective and remarkable CDK6 degradation (DC50: 2.1 nM). It inhibits the proliferation of several hematopoietic cancer cells including multiple myeloma and can degrade mutated and overexpressed CDK6. |
ターゲット&IC50 | Cereblon:, CDK6:2.1 nM (Dc50) |
In vitro | In human glioblastoma U251 cells, CP-10 induces nearly 72% degradation of CDK6 at 10 nM and 89% at 100 nM. The degradation of CDK4 induced by CP-10 is far weaker than that of CDK6 (DC50: 50-80 fold). CP-10 displays a cell inhibition potential in mantle cell lymphoma cells (in Mino, IC50≈8 nM) and multiple myeloma cell MM.1S (IC50≈10 nM). |
分子量 | 871.94 |
分子式 | C44H49N13O7 |
CAS No. | 2366268-80-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 200 mg/mL (229.37 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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CP-10 2366268-80-4 Cell Cycle/Checkpoint CDK CP10 CP 10 Inhibitor inhibitor inhibit