Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity.
説明 | CPUY074020 is a potent and orally bioavailable inhibitor of histone methyltransferase G9a (IC50: 2.18 μM) with anti-proliferative activity. |
ターゲット&IC50 | G9a:2.18 μM |
In vitro | CPUY074020 (2.5-10μM ; 48 hours) dose-dependently de-regulates H3K9 trimethylation. CPUY074020 (2-8μM; 24 hours) induces cell death through apoptosis[1]. |
In vivo | CPUY074020 shows reasonable PK properties, with a T1/2 value of 4.0 hours and an oral bioavailability of 55.5% at an oral dose of 10 mg/kg[1]. |
分子量 | 416.52 |
分子式 | C25H28N4O2 |
CAS No. | 902279-44-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 4.17 mg/mL (10 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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CPUY074020 902279-44-1 Chromatin/Epigenetic Histone Methyltransferase CPUY 074020 CPUY-074020 Inhibitor inhibitor inhibit