Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM.
説明 | CSF1R-IN-1 is a CSF1R inhibitor with IC50 of 0.5 nM. |
ターゲット&IC50 | CSF1R:0.5 nM |
In vitro | It is believed that CSF1R plays an important role in the recruitment and differentiation of tumor-associated macrophages (TAM). CSF1R-IN-1 showed good intestinal permeability in Caco2 analysis. |
In vivo | CSF1R-IN-1 has good pharmacokinetics when administered orally to mice. It seems suitable for in vivo pharmacological testing in an appropriate preclinical tumor model to prove a proof of concept. |
分子量 | 479.45 |
分子式 | C25H20F3N5O2 |
CAS No. | 2095849-04-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 83.33 mg/mL (173.80 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
CSF1R-IN-1 2095849-04-8 Tyrosine Kinase/Adaptors c-Fms Inhibitor inhibit CSF1R IN 1 colony stimulating factor 1 receptor CSF1RIN1 CSF-1R-IN-1 CSF1R CSF-1R CSF-1 receptor inhibitor