Powder: -20°C for 3 years | In solvent: -80°C for 1 year
CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively).
説明 | CSF1R-IN-2 is an oral-active SRC, MET and c-FMS inhibitor (IC50s: 0.12 nM, 0.14 nM and 0.76 nM for SRC, MET and c-FMS respectively). |
ターゲット&IC50 | MET:0.14 nM , c-Fms:0.76 nM , Src:0.12 nM |
In vitro | The suppression of MET autophosphorylation as well as the downstream STAT3 caused by CSF1R-IN-2, ERK and AKT phosphorylation at IC50 values of around 1-3 nM in SNU-5 and MKN-45 cell lines. |
In vivo | In mice, CSF1R-IN-2 (p.o., BID, 13 days) treatment results in an 85% tumor regression, and no bodyweight loss is observed after 21 days of treatment. In SCID/Beige mice. CSF1R-IN-2 (p.o., BID, 10 days) demonstrates the ability to inhibit tumor growth at 44% and 67% at the dose of 5 mg/kg, BID, and 15 mg/kg, BID, respectively. In mice, CSF1R-IN-2 inhibits MET activity in MKN-45 tumors following oral administration. |
分子量 | 409.42 |
分子式 | C20H20FN7O2 |
CAS No. | 2271119-26-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 25 mg/mL (61.06 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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CSF1R-IN-2 2271119-26-5 Angiogenesis Tyrosine Kinase/Adaptors c-Met/HGFR c-Fms Src colony stimulating factor 1 receptor CSF-1R CSF1R IN 2 inhibit CSF1RIN2 CSF1R CSF-1R-IN-2 Inhibitor CSF-1 receptor inhibitor