Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-κB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling.
説明 | Capillarisin is a novel blocker of STAT3 activation and thus may have a potential in negative regulation of growth, metastasis, and chemoresistance of tumor cells, it inhibits cancer cell growth of osteosarcoma cells by inducing apoptosis accompanied with G0/G1-phase cell cycle arrest and loss in mitochondrial membrane potential.Capillarisin has anti-inflammatory activity, can inhibit LPS-induced inflammation by blocking TLR4-mediated NF-κB and MAPKs activation in BV2 microglia. Capillarisin possesses promising anti-hyperalgesic and anti-allodynic effects through the inhibition of various inflammatory pain signaling. |
植物由来 |
分子量 | 316.26 |
分子式 | C16H12O7 |
CAS No. | 56365-38-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
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Capillarisin 56365-38-9 Angiogenesis Apoptosis Cell Cycle/Checkpoint DNA Damage/DNA Repair GPCR/G Protein Immunology/Inflammation JAK/STAT signaling MAPK Neuroscience NF-Κb Proteases/Proteasome Stem Cells Tyrosine Kinase/Adaptors STAT Prostaglandin Receptor JNK DNA/RNA Synthesis BCL VEGFR IL Receptor MMP ERK TLR TNF NF-κB NOS COX Inhibitor inhibitor inhibit