Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 7,500 | |||
2 mg | 在庫あり | ¥ 10,500 | |||
5 mg | 在庫あり | ¥ 17,000 | |||
10 mg | 在庫あり | ¥ 25,000 | |||
25 mg | 在庫あり | ¥ 41,000 | |||
50 mg | 在庫あり | ¥ 62,500 | |||
100 mg | 在庫あり | ¥ 91,500 | |||
500 mg | 在庫あり | ¥ 215,000 |
説明 | Ceramides Mixture, an endogenous ceramide, consists of hydroxy and non-hydroxy fatty acid-containing ceramides. It is involved in the regulation of cell cycle arrest, growth inhibition, and modulation of telomerase activity. |
In vitro | Endogenous Ceramides inhibits mRNA synthesis of telomerase reverse transcriptase and telomerase activity via inactivation of the c-Myc transcription factor in the A549 human lung adenocarcinoma cell line. The sustained generation of long-chain endogenous ceramide requires the biochemical recycling of the sphingosine backbone of C6-ceramide, which involves deacylation and reacylation of ceramide for the generation of endogenous long-chain ceramide, most likely by CoA-dependent ceramide synthase, which is inhibited by fumonisin B1. In A549 cells the generation of long-chain endogenous ceramide mediates the effects of exogenous C6-ceramide on growth inhibition, cell cycle arrest, and the modulation of telomerase activity [1]. |
分子量 | 581.967 |
分子式 | C36H71NO4 |
CAS No. | 100403-19-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Methanol: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: 1mg/ml(1.72mM), Sonication and heating for 30 minutes are recommended.
H2O: < 1 mg/mL (insoluble or slightly soluble)
DMSO: < 1 mg/mL (insoluble or slightly soluble)
Chloroform: 7.69mg/ml (13.2mM)
You can also refer to dose conversion for different animals. 詳細
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Ceramides Mixture 100403-19-8 DNA Damage/DNA Repair Telomerase inhibit permeability transcription CoA Golgi Inhibitor mRNA c-Myc lipid cell-cycle barrier Endogenous inhibitor