Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM.
説明 | Cerdulatinib hydrochloride (PRT2070 hydrochloride) is an oral active, multi-targeted tyrosine kinase inhibitor with IC50 of 12 nM/6 nM/8 nM/0.5 nM and 32 nM for JAK1/JAK2/JAK3/TYK2 and Syk, respectively. Also inhibits 19 other tested kinases with IC50 less than 200 nM. |
ターゲット&IC50 | JAK2:6 nM, JAK1:12 nM, TYK2:0.5 nM, JAK3:8 nM, Syk:32 nM |
別名 | Cerdulatinib, PRT2070, PRT062070 hydrochloride, PRT062070, PRT2070 hydrochloride |
分子量 | 482 |
分子式 | C20H28ClN7O3S |
CAS No. | 1369761-01-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: < 1 mg/mL (insoluble or slightly soluble)
Ethanol: < 1 mg/mL (insoluble or slightly soluble)
DMSO: 40 mg/mL (83 mM)
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Cerdulatinib hydrochloride 1369761-01-2 Angiogenesis Chromatin/Epigenetic JAK/STAT signaling MAPK Stem Cells Tyrosine Kinase/Adaptors JAK Syk MLK c-Fms Tyrosine Kinases Hippo pathway Inhibitor Cerdulatinib PRT2070 malignancies Tyk2 PRT-2070 PRT-062070 Hydrochloride PRT 062070 Hydrochloride PRT-2070 Hydrochloride PRT 2070 Hydrochloride PRT062070 Hydrochloride Janus kinase PRT2070 Hydrochloride Cerdulatinib Hydrochloride autoimmune dual PRT 062070 B-cell PRT-062070 Spleen tyrosine kinase PRT062070 hydrochloride PRT062070 PRT 2070 inhibit PRT2070 hydrochloride inhibitor