Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity.
| 説明 | Chebulinic acid is a potent inhibitor of M. tuberculosis DNA gyrase. It also can inhibit SMAD-3 phosphorylation and H+ K+-ATPase activity. |
| ターゲット＆IC50 | H+ K+-ATPase:IC50 : 65.01 μg/ml |
| In vitro | Chebulinic acid obviously inhibited HQ/Cu(II)- and H(2)O(2)/Cu(II)-mediated pBR322 DNA strand breaks. When MRC-5 cells were treated with HQ/Cu(II), the presence of Chebulinic acid inhibited HQ/Cu(II)-mediated double-strand breaks of genomic DNA [1]. |
| In vivo | Chebulinic acid had no effect on KCl-induced aortic contraction, but irreversibly inhibited the contractile responses to phenylephrine in an apparently non-competitive manner. Chebulinic acid also inhibited contractile responses of rat aorta to 5-hydroxytryptamine and angiotensin II. 3. Chebulinic acid inhibited the binding of [3H]-prazosin to dog aortic microsomal membranes in a concentration-dependent manner with an IC50 value of 0.34 mmol/L [2]. |
| 植物由来 |
| 分子量 | 956.68 |
| 分子式 | C41H28O27 |
| CAS No. | 18942-26-2 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 27.5 mg/mL (28.75 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
投与量変換You can also refer to dose conversion for different animals. 詳細
In vivo投与量計算 (透明溶液)計算器bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
Chebulinic acid 18942-26-2 Cell Cycle/Checkpoint DNA Damage/DNA Repair Membrane transporter/Ion channel Microbiology/Virology Stem Cells Antibacterial TGF-beta/Smad Proton pump ATPase DNA/RNA Synthesis Inhibitor Transforming growth factor beta inhibit Proton Pump inhibitor
