store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathway.
説明 | Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathway. |
In vitro | Cirsilineol (0.1, 1, 10 μM) dose-dependently inhibits single mixed lymphocyte reaction and the proliferation of Concanava A-induced T-cells in Splenocytes. Cirsilineol (1, 5, 10 μM) inhibits IFN-γ-induced Tyr701 phosphorylation of STAT1 and the activation of JAK2 in Splenic CD4+ T cells[3]. |
In vivo | In female C57BL/6, BALB/c, and DO11.10 transgenic mice with TNBS, Cirsilineol (3-30 mg/kg) reduces inflammatory infiltration, restores the destructive mucosal architecture, and remisses edema thus improving the effects on the body weights and survival rate of mice. Cirsilineol ameliorates TNBS-induced Th1-mediated colitis by inhibiting IFN-γ/STAT1/T-bet signaling in CD4+ T cells[1]. |
別名 | Fastigenin, SPM 927, Eupatrin |
分子量 | 344.32 |
分子式 | C18H16O7 |
CAS No. | 41365-32-6 |
store at low temperature,keep away from direct sunlight
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
You can also refer to dose conversion for different animals. 詳細
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Cirsilineol 41365-32-6 Apoptosis Immunology/Inflammation JAK/STAT signaling Neuroscience Stem Cells STAT COX SPM-927 Fastigenin SPM 927 Eupatrin SPM927 Inhibitor inhibitor inhibit