Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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5 mg | 在庫あり | ¥ 9,000 | |||
10 mg | 在庫あり | ¥ 13,000 | |||
25 mg | 在庫あり | ¥ 18,500 | |||
50 mg | 在庫あり | ¥ 27,500 | |||
100 mg | 在庫あり | ¥ 41,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 11,500 |
説明 | Astramembrangenin (Cycloastragenol (Astramembrangenin)) is a triterpenoid saponin compound and a hydrolysis product of the main active ingredient in Astragalus membranaceus. Cycloastragenol (CAG) may have a novel therapeutic role in depression |
In vitro | Cyclogalegenol has important anti-inflammatory activity by inhibiting lymphocytes activation, proliferation and cytokines expression, this effect may be related to reduction of overall intracellular Ca2+ overload[1]. |
In vivo | oral administration of Cyclogalegenol for 7 days attenuated depression-like behavior in experimental mice.Cyclogalegenol stimulates telomerase activity in human neonatal keratinocytes and rat neuronal cells, and induces CREB activation followed by tert and bcl2 expression. Furthermore, Cyclogalegenol may have a novel therapeutic role in depression[2]. |
細胞研究 | Mouse lymphocytes were obtained from spleens and subjected to Con A for 24?h. Herein, the cells were treated with different concentrations of Cyclogalegenol. Cell viability was assayed by MTT. Pretreated by Cyclogalegenol?and stimulated?by Con A,?the expression of CD69 and CD25, Th1/Th2/Th17 cytokines, cell cycle, proliferation and intracellular Ca2+ concentration ([Ca2+]i) were analyzed by flow cytometry[1]. |
動物実験 | Mice were administered Cyclogalegenol?100 mg/kg, or water by oral gavage, or imipramine 15 mg/kg , a currently?used tricyclic antidepressant, by intraperitoneal injection for 7 days as well as 45 min before testing.?The forced swim test was performed as described previously , by placing a mouse in a glass cylinder (height: 30 cm, diameter: 15 cm) filled with water to a depth of 12 cm.?Mice were tested in the cylinder for 6 min. The water was changed before testing another animal.?All test sessions were recorded.?Depression-like behavior was determined by observing the immobility of the mouse, where immobility is defined as when a mouse floats passively in the water with minimal movement to keep its head above the water.?The total period of immobility during the last 4 min of the test session was determined[2]. |
植物由来 |
別名 | Cyclogalegenol, Astramembrangenin |
分子量 | 490.71 |
分子式 | C30H50O5 |
CAS No. | 78574-94-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 98 mg/mL (199.71 mM)
You can also refer to dose conversion for different animals. 詳細
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Cycloastragenol 78574-94-4 Chromatin/Epigenetic DNA Damage/DNA Repair Epigenetic Reader Domain Telomerase bone Cyclogalegenol cerebral Cyclosieversigenin loss microglia ameliorated neuroinflammation Inhibitor inhibit reperfusion Astramembrangenin inhibitor