Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation.
説明 | DPH is a potent cell permeable activator of c-Abl. It shows potent enzymatic and cellular activity in stimulating c-Abl activation. |
In vitro | DPH represents the first cell-permeable, small-molecule tool compound for c-Abl activation. DPH binds to the myristoyl binding site. It also prevents the formation of the bent conformation of the αI helix through steric hindrance. Which is a mode of action distinct from the previously identified allosteric c-Abl inhibitor, GNF-2, that also binds to the myristoyl binding site [1]. |
分子量 | 336.32 |
分子式 | C18H13FN4O2 |
CAS No. | 484049-04-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (267.6 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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DPH 484049-04-9 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors Bcr-Abl Inhibitor inhibitor inhibit