Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS).
説明 | Danicopan (ACH-4471) (ACH-4471) is a selective, orally active small molecule factor D inhibitor with high binding affinity to human factor D, with a Kd value of 0.54 nM. Danicopan (ACH-4471) inhibits the activity of the complement replacement pathway (APC) and may block the complement replacement pathway in paroxysmal nocturnal hemoglobinuria (PNH) and atypical hemolytic uremic syndrome (aHUS). |
ターゲット&IC50 | FD:(kd)0.54 nM |
In vitro | Danicopan (ACH-4471) inhibits the proteolytic activity of purified factor D and its natural substrate factor B binding to C3b, blocking the production of Bb fragments in a dose-dependent manner, with an IC50 value of 0.015 μM. Danicopan (ACH-4471) effectively inhibits hemolysis with IC50 values from 0.0040 μM to 0.027 μM (IC90 values from 0.015 μM to 0.11 μM). |
別名 | ACH-4471 |
分子量 | 580.41 |
分子式 | C26H23BrFN7O3 |
CAS No. | 1903768-17-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 260 mg/mL (447.96 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Danicopan 1903768-17-1 Immunology/Inflammation Complement System ACH 4471 inhibit ACH4471 ACH-4471 Inhibitor inhibitor