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Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and 0.04 nM, respectively. Durvalumab is often used in combination with platinum-based compounds for the treatment of non-small cell lung cancer and advanced hepatocellular carcinoma cells.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
1 mg | 在庫あり | ¥ 52,500 |
5 mg | 在庫あり | ¥ 124,000 |
10 mg | 在庫あり | ¥ 178,500 |
25 mg | 在庫あり | ¥ 271,000 |
50 mg | 在庫あり | ¥ 365,000 |
100 mg | 在庫あり | ¥ 489,000 |
説明 | Durvalumab (MEDI 4736) is a humanized monoclonal antibody targeting PD-L1. It can block the interaction of PD-L1 with PD-1 and CD80, with IC50 values of 0.1 and 0.04 nM, respectively. Durvalumab is often used in combination with platinum-based compounds for the treatment of non-small cell lung cancer and advanced hepatocellular carcinoma cells. |
ターゲット&IC50 | PD-L1/CD80:0.04 nM, PD-1/PD-L1:0.1 nM |
In vivo | In a mouse xenograft model of human melanoma ( A375 ) and pancreatic ( HPAC ) tumor cell lines, Durvalumab inhibits tumor growth through a T cell-mediated mechanism. Compared with the isotype-matched control antibody Durvalumab, both HPAC and A375 xenografts significantly inhibited tumor growth ( 5-0.01 mg / kg for NOD / SCID mice with HPAC tumors ; 5-0.1mg / kg for NOD / SCID mice with A375 tumor ; intraperitoneal administration ; twice a week ; for 3 weeks ), 74 % HPAC cell growth inhibition and 77 % A375 cell growth inhibition were achieved. However, when administered in the absence of T cells, Durvalumab had no effect on the growth of A375 tumor xenografts. [ 2 ] |
別名 | MEDI 4736 |
分子量 | N/A |
CAS No. | 1428935-60-7 |
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store at -20°C
You can also refer to dose conversion for different animals. 詳細
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Durvalumab 1428935-60-7 Apoptosis Cell Cycle/Checkpoint Immunology/Inflammation PD-1/PD-L1 MEDI-4736 MEDI4736 MEDI 4736 Inhibitor inhibitor inhibit