Powder: -20°C for 3 years | In solvent: -80°C for 1 year
FAUC-365 is a D3 dopamine receptor agonist.
説明 | FAUC-365 is a D3 dopamine receptor agonist. |
ターゲット&IC50 | 5-HT:0.50 nM(Ki) |
In vitro | As a dichloro derivative, FAUC-365 revealed D3 affinities that were comparable to its methoxy-substituted analogs, however, the selectivities of FAUC-365 against 5HT-1A, 5-HT2, and R1 were substantially higher, which was demonstrated by the extraordinary selectivity ratios of 17600, 7200, 5200, and 680 over D1, D2long, D2short, and D4, respectively, were determined for FAUC-365 with Ki of 0.50 nM. In addition, the benzothiophene analog FAUC 346 and its oxa analog showed partial agonist character with EC50 values at 0.36 and 1.5 nM, respectively [1]. |
別名 | FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide, FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide |
分子量 | 462.44 |
分子式 | C23H25Cl2N3OS |
CAS No. | 474432-66-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: insoluble
DMSO: 50 mg/mL (108.12 mM)
EtOH: insoluble
You can also refer to dose conversion for different animals. 詳細
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FAUC-365 474432-66-1 GPCR/G Protein Neuroscience Dopamine Receptor inhibit Parkinson's disease FAUC365 D3 receptor Dopamine Inhibitor schizophrenia SPET FAUC 365 FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide Radioligand FAUC-365 Benzo[b]thiophene-2-carboxylic acid {4-[4-(2,3-dichloro- phenyl)-piperazin-1-yl]-butyl}-amide inhibitor