Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants.
説明 | Flumatinib mesylate (HHGV678 mesylate) is a selective inhibitor of c-Abl, PDGFRβ and c-Kit, effectively overcomes drug resistance of certain KIT mutants. |
In vitro | In vivo study consistently suggested that flumatinib had superior efficacy compared with imatinib or sunitinib against 32D cells with the secondary mutation Y823D.?Molecular modeling of flumatinib docked to the KIT kinase domain suggested a special mechanism underlying the capability of flumatinib to overcome the drug-resistance conferred by activation loop mutations.?These findings suggest that flumatinib could be a promising therapeutic agent against GISTs resistant to both imatinib and sunitinib because of secondary mutations in the activation loop[1]. |
別名 | HHGV678 mesylate |
分子量 | 658.69 |
分子式 | C30H33F3N8O4S |
CAS No. | 895519-91-2 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 50 mg/mL (75.91 mM)
DMSO: 50 mg/mL (75.91 mM)
You can also refer to dose conversion for different animals. 詳細
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Flumatinib mesylate 895519-91-2 Angiogenesis Cytoskeletal Signaling Tyrosine Kinase/Adaptors PDGFR Bcr-Abl c-Kit HHGV-678 PDGFRβ HHGV678 c-Abl Platelet-derived growth factor receptor Flumatinib Mesylate HHGV 678 HHGV-678 Mesylate SCFR Flumatinib CD117 HHGV 678 Mesylate HHGV678 mesylate Inhibitor HHGV678 Mesylate inhibit inhibitor