Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 38,000 | |||
10 mg | 在庫あり | ¥ 67,000 | |||
25 mg | 在庫あり | ¥ 112,000 | |||
50 mg | 在庫あり | ¥ 164,000 | |||
100 mg | 在庫あり | ¥ 226,500 |
説明 | GSK-3β inhibitor 1 is an inhibitor of GSK-3β( IC50 of 4.9 nM) and demonstrates high antidiabetic efficacy. |
ターゲット&IC50 | GSK-3β:4.9 nM |
In vivo | GSK-3β inhibitor 1(compound 3a) inhibits GSK-3β with IC50 4.19 nM. In a cell-based assay 3a shows no significant leucocyte toxicity at 10 M and is moderately cytotoxic against A549 cells. Compound 3a demonstrated high antidiabetic efficacy in obese streptozotocin-treated rats improving glucose tolerance at a dose of 50 mg/kg body weight thus representing an interesting lead for further optimization. |
分子量 | 222.24 |
分子式 | C14H10N2O |
CAS No. | 187325-53-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30 mg/mL (134.99 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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GSK-3β inhibitor 1 187325-53-7 PI3K/Akt/mTOR signaling Stem Cells GSK-3 inhibit Glycogen synthase kinase 3 Glycogen synthase kinase-3 GSK3β inhibitor 1 Inhibitor GSK-3b inhibitor 1 GSK 3β inhibitor 1 GSK-3beta inhibitor 1 inhibitor