store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with anticancer and antitumor activity, inhibiting PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, and can be used to study advanced solid tumors.
説明 | GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) is an orally active and potent inhibitor of type I protein arginine methyltransferases (PRMTs) with anticancer and antitumor activity, inhibiting PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, and can be used to study advanced solid tumors. |
ターゲット&IC50 | PRMT3:48 nM, PRMT1:3.1 nM, PRMT6:5.7 nM, PRMT4:1148 nM, PRMT8:1.7 nM |
In vitro | In the majority of 249 cancer cell lines representing 12 tumor types, GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) exhibits 50% or more growth inhibition relative to DMSO-treated cells[1]. |
In vivo | GSK3368715 dihydrochloride (EPZ019997 dihydrochloride) significantly affects the growth of BxPC3 xenografts at all doses tested. In the 150- and 300-mg/kg dose groups, it reduces tumor growth by 78% and 97%, respectively[1]. |
別名 | EPZ019997 dihydrochloride, GSK3368715 2HCl, EPZ019997 2HCl |
分子量 | 439.46 |
分子式 | C20H40Cl2N4O2 |
CAS No. | 1628925-77-8 |
store under nitrogen
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 100 mg/mL (227.55 mM), sonification is recommended.
DMSO: 100 mg/mL (227.55 mM), sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
GSK3368715 dihydrochloride 1628925-77-8 Chromatin/Epigenetic Histone Methyltransferase EPZ019997 dihydrochloride GSK 3368715 GSK-3368715 Dihydrochloride EPZ-019997 EPZ 019997 Dihydrochloride GSK-3368715 GSK3368715 2HCl GSK3368715 Dihydrochloride EPZ 019997 EPZ019997 EPZ019997 2HCl EPZ-019997 Dihydrochloride GSK 3368715 Dihydrochloride GSK3368715 Inhibitor inhibitor inhibit