Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,000 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 34,000 | |||
25 mg | 在庫あり | ¥ 66,500 | |||
50 mg | 在庫あり | ¥ 102,500 | |||
100 mg | 在庫あり | ¥ 151,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 28,500 |
説明 | Indirubin-3′-oxime is an effective inhibitor of cyclin-dependent protein kinases, and may play an obligate role in neuronal apoptosis in Alzheimer's disease. |
ターゲット&IC50 | JNK3:1 μM (IC50), JNK1:0.8 μM (IC50), JNK2:1.4 μM (IC50) |
In vitro | clear efficacy of I3M + Tq combinations in LC models mediated by suppressing Akt/mTOR/NFκB signalling. |
In vivo | indirubin-3'-monoxime improved the morphology and increased the survival rate of SH-SY5Y cells exposed to amyloid-beta 25-35 (Aβ25-35), and also suppressed apoptosis by reducing tau phosphorylation at Ser199 and Thr205.?Furthermore, indirubin-3'-monoxime inhibited phosphorylation of glycogen synthase kinase-3β (GSK-3β).?indirubin-3'-monoxime reduced Aβ25-35-induced apoptosis by suppressing tau hyperphosphorylation via a GSK-3β-mediated mechanism.?Indirubin-3'-monoxime is a promising drug candidate for Alzheimer's disease. |
別名 | Indirubin-3'-monoxime |
分子量 | 277.28 |
分子式 | C16H11N3O2 |
CAS No. | 667463-82-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/ml (198.36 mM)
You can also refer to dose conversion for different animals. 詳細
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Indirubin-3′-oxime 667463-82-3 Cell Cycle/Checkpoint MAPK PI3K/Akt/mTOR signaling Stem Cells GSK-3 JNK CDK antiplatelet IDR3O Glycogen synthase kinase-3 induced phosphorylation indirubin Inhibitor Cyclin dependent kinase Indirubin3′oxime chondrocytes collagen I3O Glycogen synthase kinase 3 MEF2D Indirubin 3′ oxime Indirubin-3'-monoxime inhibit inhibitor