LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM.
| パッケージサイズ | 在庫状況 | 単価(税別) | ||
|---|---|---|---|---|
| 無料サンプル 1 mg | ||||
| 1 mg | 在庫あり | ￥ 42000 | ||
| 2 mg | 在庫あり | ￥ 62500 | ||
| 5 mg | 在庫あり | ￥ 84000 | ||
| 10 mg | 在庫あり | ￥ 142000 | ||
| 25 mg | 在庫あり | ￥ 228500 | ||
| 50 mg | 在庫あり | ￥ 393500 | ||
| 100 mg | 在庫あり | お問い合わせ | ||
| 1 mL * 10 mM (in DMSO) | 在庫あり | ￥ 91500 | ||
| 説明 | LNP023 hydrochloride is an orally bioavailable, highly potent and highly selective factor B inhibitor with an IC50 of 10 nM. LNP023 shows direct, reversible, and high-affinity binding to human factor B with a KD of 7.9 nM. |
| In vitro | LNP023 demonstrates excellent selectivity over other proteases affording IC50 values of >30 μM across a panel of 41 human proteases, including the AP protein factor D (>100 μM)[3]. |
| In vivo | LNP023 (20-180 mg/kg; oral administration) is effective upon prophylactic and therapeutic dosing in an experimental model of membranous nephropathy in rats and prevents KRN (150 μL)-induced arthritis in mice[2]. After oral administration (rat 30 and, dog 10 mg/kg), LNP023 exhibits moderate half-lives (T1/2; Wistar Han rats 3.4 h, beagle dogs 5.5 h) and Cmax (Wistar Han rats 410 nM, beagle dogs 2200 nM)[3]. |
| 別名 | LNP 023, hemoglobinuria, inhibit, PNH, Iptacopan hydrochloride, atypical, pathogenesis, LNP023 hydrochloride, Inhibitor, LNP023, factor B, system, Iptacopan, Complement System, complement, Iptacopan HCl, paroxysmal, syndrome, LNP-023, pathway, hemolytic, uremic, alternative, nocturnal |
| 分子量 | 458.98 |
| 分子式 | C25H31ClN2O4 |
| CAS No. | 1646321-63-2 |
Powder: -20°C for 3 years In solvent: -80°C for 2 years
H2O: 50 mg/mL (108.94 mM), ultrasonic and warming
DMSO: 250 mg/mL (544.69 mM), Need ultrasonic
( < 1 mg/ml refers to the product slightly soluble or insoluble )
引用文献
投与量変換You can also refer to dose conversion for different animals. 詳細
In vivo投与量計算 (透明溶液)計算器bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
