Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 19,500 | |||
5 mg | 在庫あり | ¥ 45,500 | |||
10 mg | 在庫あり | ¥ 72,000 | |||
25 mg | 在庫あり | ¥ 122,500 | |||
50 mg | 在庫あり | ¥ 176,500 | |||
100 mg | 在庫あり | ¥ 248,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 52,000 |
説明 | JR14a (5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride) is a potent antagonist of human complement C3a receptor. |
In vitro |
In vitro, thiophene compounds potently inhibited intracellular Ca2+ release in human macrophages without inhibiting the agonist effects in the same concentration range as the related Complement protein C5a[1]. |
In vivo | JR14a reduces mast cell degranulation and macrophage infiltration in BR103-induced rat paw edema[1]. |
別名 | 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride |
分子量 | 533.47 |
分子式 | C25H26Cl2N4O3S |
CAS No. | 2411440-41-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 90 mg/mL (168.71 mM), Sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
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JR14a 2411440-41-8 Immunology/Inflammation Complement System inflammation Inhibitor inhibit C3a 5-(Bis(4-chlorophenyl)methyl)-3-methylthiophene-2-carbonyl)-l-arginine hydrochloride JR-14a complement inhibitor