Powder: -20°C for 3 years | In solvent: -80°C for 1 year
JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約8-10 週間 | ¥ 385,500 |
50 mg | 約8-10 週間 | ¥ 503,000 |
100 mg | 約8-10 週間 | ¥ 711,500 |
説明 | JTE-952 is a oral, potent active and selective Type II inhibitor of colony stimulating factor-1 receptor (CSF-1R or cFMS, type III receptor tyrosine kinase), with IC50 values of 13 nM and 261 nM for CSF1R and TrkA , respectively. Effective against a mouse collagen-induced model of arthritis. |
ターゲット&IC50 | TrkA:261 nM , CSF1R:13 nM |
In vivo | JTE-952 treatment reduces the overall progression of the clinical score, including inflammation and bone erosion in mouse model of collagen-induced arthritis (CIA model). |
分子量 | 518.6 |
分子式 | C30H34N2O6 |
CAS No. | 1255303-54-8 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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JTE-952 1255303-54-8 GPCR/G Protein Immunology/Inflammation Neuroscience Histamine Receptor JTE 952 JTE952 Inhibitor inhibitor inhibit