Powder: -20°C for 3 years | In solvent: -80°C for 1 year
KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
無料サンプル 1 mg | |||||
1 mg | 在庫あり | ¥ 23,000 | |||
5 mg | 在庫あり | ¥ 47,500 | |||
10 mg | 在庫あり | ¥ 85,000 | |||
25 mg | 在庫あり | ¥ 143,000 | |||
50 mg | 在庫あり | ¥ 203,500 | |||
100 mg | 在庫あり | ¥ 273,500 | |||
500 mg | 在庫あり | ¥ 558,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 58,500 |
説明 | KY19382 (2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382) is a potent and orally active dual inhibitor of CXXC5-DVL and GSK3β( IC50s of 19 and 10 nM, respectively). It activates Wnt/β-catenin signaling through inhibitory effects on both CXXC5-DVL interaction and GSK3β activity. KY19382 can be used for the research of high fat diet (HFD) induced metabolic diseases. |
ターゲット&IC50 | CXXC5-DVL:10 nM, GSK-3β:10 nM |
別名 | 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382, A3051 |
分子量 | 360.19 |
分子式 | C17H11Cl2N3O2 |
CAS No. | 2226664-93-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 5 mg/mL (13.88 mM), sonification is recommended.
You can also refer to dose conversion for different animals. 詳細
bottom
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
KY19382 2226664-93-1 Cytoskeletal Signaling Others PI3K/Akt/mTOR signaling Stem Cells GSK-3 Wnt/beta-catenin Glycogen synthase kinase 3 KY 19382 Beta catenin β-catenin 2H-Indol-2-one, 5,6-dichloro-3-[1,3-dihydro-3-(methoxyimino)-2H-indol-2-ylidene]-1,3-dihydro-Ky19382 inhibit Wnt Inhibitor A 3051 A-3051 A3051 KY-19382 Glycogen synthase kinase-3 inhibitor