LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β .
| 説明 | LSKL, Inhibitor of Thrombospondin TSP-1 acetate is activation of TGF-β . |
| In vivo | Administration of LSKL peptide attenuated Smad2 phosphorylation at 6 h. S-phase entry of hepatocytes was accelerated at 24 and 48 h by LSKL peptide, which resulted in faster recovery of the residual liver and bodyweight.?Haematoxylin and eosin tissue staining and blood biochemical examinations revealed no significant adverse effects following the two LSKL peptide administrations.?In the clinical setting, plasma TSP-1 levels were lowest on the first day after hepatectomy.?However, plasma TSP-1 levels at this stage were significantly higher in patients with subsequent liver dysfunction compared with levels in those without liver dysfunction following hepatectomy |
| 動物実験 | Mice were operated on with a 70 per cent hepatectomy or sham procedure. Operated mice received either LSKL peptide or normal saline intraperitoneally at abdominal closure and 6 h after hepatectomy. Perioperative plasma TSP-1 levels were measured by enzyme-linked immunosorbent assay in patients undergoing hepatectomy. |
| 別名 | LSKL, Inhibitor of Thrombospondin TSP-1 |
| 分子量 | 686.64 |
| 分子式 | C25H44F6N6O9 |
| CAS No. | T7676 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 27.5 mg/mL (40.05 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
参考文献
投与量変換You can also refer to dose conversion for different animals. 詳細
In vivo投与量計算 (透明溶液)計算器bottom
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LSKL, Inhibitor of Thrombospondin TSP-1 acetate T7676 Stem Cells TGF-beta/Smad LSKL, Inhibitor of Thrombospondin TSP1 acetate LSKL, Inhibitor of Thrombospondin TSP 1 acetate LSKL, Inhibitor of Thrombospondin TSP-1 Inhibitor inhibitor inhibit
