Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM).
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
無料サンプル 1 mg | |||||
1 mg | 在庫あり | ¥ 9,000 | |||
2 mg | 在庫あり | ¥ 12,500 | |||
5 mg | 在庫あり | ¥ 27,000 | |||
10 mg | 在庫あり | ¥ 34,500 | |||
25 mg | 在庫あり | ¥ 76,500 | |||
50 mg | 在庫あり | ¥ 103,000 | |||
100 mg | 在庫あり | ¥ 151,000 | |||
500 mg | お問い合わせ | ¥ 317,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 29,000 |
説明 | LY2584702 is a selective, ATP-competitive p70S6K inhibitor(IC50: 4 nM). |
ターゲット&IC50 | p70S6K:4 nM |
In vitro |
In HCT116 colon cancer cells, LY2584702 inhibits phosphorylation of the S6 ribosomal protein (pS6) with IC50 of 0.1-0.24 μM[1]. Combined with EGFR inhibitor erlotinib or with the mTOR inhibitor everolimus, LY2584702 has significant synergistic effects [2]. |
In vivo |
LY2584702 (12.5 mg/kg BID), shows significant antitumor activity in both U87MG glioblastoma and HCT116 colon carcinoma xenograft models. [1] |
分子量 | 445.42 |
分子式 | C21H19F4N7 |
CAS No. | 1082949-67-4 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 1 mg/mL(2.24 mM), warmed
DMSO: 10 mM, warmed with 50oC water bath
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
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