Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Ly-2584702 hydrochloride is a p70S6K selective ATP competitive inhibitor with IC50 of 4 nM.In the S6K1 enzyme assay, the IC50 of LY-2584702 was 2 nM.
パッケージサイズ | 在庫状況 | 単価(税別) |
---|---|---|
25 mg | 約6-8 週間 | ¥ 349,000 |
50 mg | 約6-8 週間 | ¥ 454,500 |
100 mg | 約6-8 週間 | ¥ 574,000 |
ターゲット&IC50 | S6K1:2 nM, p70 S6K:4 nM |
In vivo | LY-2584702 significantly inhibits tumor growth as a single agent in U87MG glioblastoma and HCT116 colon carcinoma xenograft models at doses of 2.5 mg/kg and 12.5 mg/kg twice daily (BID), achieving noteworthy tumor growth reduction at threshold minimum effective dose 50% (TMED50) of 2.3 mg/kg and TMED90 of 10 mg/kg in the HCT116 model[1]. In vivo studies involving EOMA cells expressing shAkt3 implanted in nu/nu mice show that, when treated with LY-2584702 or Rapamycin for 14 days, LY-2584702 nearly matches Rapamycin in inhibiting S6 phosphorylation, highlighting its potential mechanism of action against tumors. Additionally, while LY-2584702 does not significantly change the growth of pLKO tumors, it considerably reduces tumor growth in shAkt3 expressing tumors after a 14-day treatment period, pointing to the enhanced tumor growth in the absence of Akt3[2]. |
分子量 | 481.88 |
分子式 | C21H20ClF4N7 |
CAS No. | 1082948-81-9 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
You can also refer to dose conversion for different animals. 詳細
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LY-2584702 hydrochloride 1082948-81-9 MAPK PI3K/Akt/mTOR signaling S6 Kinase LY 2584702 hydrochloride LY2584702 Hydrochloride LY 2584702 Hydrochloride LY2584702 hydrochloride LY-2584702 Hydrochloride Inhibitor inhibitor inhibit