Powder: -20°C for 3 years | In solvent: -80°C for 1 year
LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI).
説明 | LY3200882 is a highly selective inhibitor of TGF-β receptor type 1 (TGFβRI). |
ターゲット&IC50 | TGFβRI:38.2 nM (IC50) |
In vitro | LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vitro in tumor and immune cells. LY3200882 has shown anti-metastatic activity in vitro in migration assays. In in vitro immune suppression assays, LY3200882 has shown the ability to rescue TGFβ1 suppressed or T regulatory cell suppressed na?ve T cell activity and restore proliferation [1]. |
In vivo | LY3200882 potently inhibits TGFβ mediated SMAD phosphorylation in vivo in subcutaneous tumors in a dose-dependent fashion. LY3200882 has shown anti-metastatic activity in vivo in an experimental metastasis tumor model (intravenous EMT6-LM2 model of triple negative breast cancer) [1]. |
分子量 | 435.52 |
分子式 | C24H29N5O3 |
CAS No. | 1898283-02-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 85 mg/mL
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
LY3200882 1898283-02-7 Stem Cells TGF-beta/Smad Anti-cancer ALK5 TGFβRI ATP-competitive inhibit immune phosphorylation Transforming growth factor beta receptors anti-metastatic TGF-β Receptor LY-3200882 SMAD serine-threonine Inhibitor LY 3200882 inhibitor