Powder: -20°C for 3 years | In solvent: -80°C for 1 year
M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 16,500 | |||
5 mg | 在庫あり | ¥ 41,000 | |||
10 mg | 在庫あり | ¥ 66,500 | |||
25 mg | 在庫あり | ¥ 133,000 | |||
50 mg | 在庫あり | ¥ 191,500 | |||
100 mg | 在庫あり | ¥ 264,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 48,000 |
説明 | M2698 (MSC2363318A) is an inhibitor of p70S6K, Akt1 and Akt3 with IC50s of 1 nM. M2698 shows anti-cancer activity. |
ターゲット&IC50 | Akt3:1 nM, p70 S6K:1 nM, Akt1:1 nM |
In vitro | M2698 (0.3 nM-50 M) dose-dependently inhibits proliferation in breast tumor cell lines (IC50s: 0.02-8.5 µM). M2698 (0.3-1 µM) induces feedback loop phosphorylation on Akt and suppresses Akt and p70S6K activity in HCC1419 and MDA-MB-453 cells. M2698 inhibits indirectly pGSK3β and pS6 with IC50s of 17 and 15 nM[1]. |
In vivo | Gavage administration of M2698 (10-30 mg/kg) dose-dependently inhibits the growth of tumors and increases pAkt levels in tumor tissue. M2698 (30 mg/kg) causes tumor regression. M2698 (1-20 mg/kg) inhibits S6 phosphorylation in a dose-proportional manner over time[1]. |
別名 | MSC2363318A |
分子量 | 449.86 |
分子式 | C21H19ClF3N5O |
CAS No. | 1379545-95-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 112.5 mg/mL (250.1 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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M2698 1379545-95-5 Cytoskeletal Signaling PI3K/Akt/mTOR signaling Akt mTOR M 2698 MSC2363318A M-2698 Inhibitor inhibitor inhibit