Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase.
説明 | MAP4K4-IN-3 (Compound 17) may be a viable target for antidiabetic agents, a serine/threonine protein kinase. |
ターゲット&IC50 | MAP4K4:14.9 nM |
In vitro | MAP4K4-IN-3, Antidiabetic agent.MAP4K4-IN-3 is a potent and selective MAP4K4 inhibitor with an IC50 of 14.9 nM in kinase assay, an IC50 of 470 nM in cell assay. |
In vivo | Administering MAP4K4-IN-3 (Compound 2; 25 mg/kg, b.i.d.) orally to telemetered rats over a period of five days induces several adverse reactions. Cardiovascular measurements reveal a significant increase in maximal heart rate by 25 beats per minute (bpm) compared to control groups upon treatment with MAP4K4-IN-3[2]. Additionally, there are noticeable declines in body weight (7%) and an increase in body temperature (0.4°C) against control values throughout the study. |
別名 | Compound 17 |
分子量 | 297.74 |
分子式 | C15H12ClN5 |
CAS No. | 1811510-58-3 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 8 mg/mL (26.87mM)
You can also refer to dose conversion for different animals. 詳細
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MAP4K4-IN-3 1811510-58-3 MAPK Compound 17 MAP4K MAPK Kinase Kinase Kinase Inhibitor MAP4K4 IN 3 MAP4K4IN3 inhibit MAP-4K4-IN-3 inhibitor