Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MBM-55 is an effective inhibitor of NIMA related kinase 2 (NEK2) with an IC50 of 1 nM. MBM-55 effectively inhibits the proliferation of cancer cells by inducing cell cycle arrest and apoptosis.
ターゲット&IC50 | Aurora A:5300 nM , Chk1:57 nM , DYRK1A:6.5 nM , CDK4:441nM , Abl:20 nM , CDK2:370 nM , NEK2:1 nM , GSK-3β:91 nM , Akt1:608 nM , RSK1:5.4 nM |
分子量 | 498.55 |
分子式 | C28H27FN6O2 |
CAS No. | 2083622-09-5 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 120 mg/mL (240.70 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
MBM-55 2083622-09-5 Angiogenesis Cell Cycle/Checkpoint Chromatin/Epigenetic Cytoskeletal Signaling MAPK PI3K/Akt/mTOR signaling Stem Cells Tyrosine Kinase/Adaptors GSK-3 Akt DYRK Chk Bcr-Abl CDK Aurora Kinase S6 Kinase Inhibitor arrest proliferation antitumor Apoptosis cycle cell selectivity inhibit MBM 55 Nek2 MBM55 inhibitor