keep away from direct sunlight,store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM.
説明 | MI-2-2 is an inhibitor of bivalent protein-protein interaction between menin and MLL with an IC50 of 46 nM. MI-2-2 binds to menin with Kd of 22 nM. |
In vitro | MI-2-2 is capable of inhibiting the bivalent fragment of MLL that comprises both MBM1 and MBM2 with IC50 of 520 nM. MI-2-2 potently inhibits cell proliferation, differentiation and down-regulation of Hoxa9 expression. MI-2-2 exhibits pronounced activities at low micromolar concentrations in BMCs transformed with MLL-AF9 and in MV4[1]. |
別名 | MI22, MI 2 2 |
分子量 | 415.5 |
分子式 | C17H20F3N5S2 |
CAS No. | 1454920-20-7 |
keep away from direct sunlight,store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: Soluble
You can also refer to dose conversion for different animals. 詳細
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MI-2-2 1454920-20-7 Chromatin/Epigenetic Histone Methyltransferase cell proliferation inhibit menin-MLL interaction MI 22 Epigenetic Reader Domain Inhibitor MI-22 Hoxa9 expression differentiation MI22 MI 2 2 leukemia inhibitor