Powder: -20°C for 3 years | In solvent: -80°C for 1 year
Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
---|---|---|---|---|---|
無料サンプル 1 mg | |||||
50 mg | 在庫あり | ¥ 9,500 | |||
100 mg | 在庫あり | ¥ 15,500 | |||
500 mg | 在庫あり | ¥ 30,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 10,500 |
説明 | Montelukast sodium (MK0476) is an orally available leukotriene receptor antagonist which is widely used for the prophylaxis and chronic treatment of asthma and has been linked to rare cases of clinically apparent liver injury. |
In vitro | Administering 6 mg/kg of Montelukast once daily for 20 days significantly inhibits the increase of eosinophils in both the BAL fluid and lung tissue in mice stimulated by OVA, while also elevating the IL-5 levels in the BAL fluid. OVA stimulation leads to an upsurge in CysLT1 receptor mRNA expression but a decrease in CysLT2 receptor mRNA expression. Following OVA stimulation, Montelukast suppresses the elevated expression of CysLT1 without diminishing the expression of CysLT2. |
In vivo | Montelukast acts by binding to the cysteinyl leukotriene receptor CysLT1 in the lungs and bronchi, thereby blocking the effects of leukotriene D4. This action prevents airway edema, smooth muscle contraction, and secretion of viscous liquids, reduces bronchoconstriction caused by leukotrienes, and diminishes inflammation occurrence. |
細胞研究 | Nasal mucosa and polyp epithelial cells are stimulated with fetal bovine serum (FBS) with or without MK for 24 hours, and cytokine concentrations in epithelial secretions are measured by ELISA. After incubating peripheral blood eosinophils with epithelial cell-conditioned media (ECM) with or without montelukast up to 3 days, eosinophil survival is assessed by Trypan blue dye exclusion[1]. |
別名 | MK0476 |
分子量 | 608.17 |
分子式 | C35H35ClNNaO3S |
CAS No. | 151767-02-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 30.4 mg/mL (50 mM)
DMSO: 60.8 mg/mL (100 mM)
You can also refer to dose conversion for different animals. 詳細
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Montelukast sodium 151767-02-1 GPCR/G Protein Immunology/Inflammation Leukotriene Receptor LTR Cysltr1 liver ischemia–reperfusion injury damage antioxidant intestinal Inhibitor Montelukast asthma cysteinyl icardiac inhibit leukotriene MK-0476 MK0476 MK 0476 inhibitor