store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively.
説明 | NF023 hexasodium is a selective and competitive P2X1 receptor antagonist, with IC50 values of 0.21 μM, 28.9 μM, > 50 μM and > 100 μM for human P2X1, P2X3, P2X2, and P2X4-mediated responses respectively. |
In vitro | NF023 is selective for recombinant Gi alpha-1 and recombinant Go alpha (EC50 value of approximately 300 nM)[2]. NF023 inhibits P2X1 receptors in a voltage-insensitive manner. NF023 (5 and 30 μM) causes a shift of the concentration-response curve to the right without affecting the maximal response to ATP (KB=1.190.2 μM)[4]. |
In vivo | NF023 (100 µmol/kg i.v.) antagonizes vasopressor responses to α,β-mATP but not to noradrenaline In pithed rats[3]. |
別名 | NF 023, NF 023 hexasodium |
分子量 | 1168.92 |
分子式 | C35H26N4Na6O21S6 |
CAS No. | 104869-31-0 |
store at low temperature
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 105.3mg/mL (90.1mM)
You can also refer to dose conversion for different animals. 詳細
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NF023 hexasodium 104869-31-0 Membrane transporter/Ion channel Neuroscience P2X Receptor NF 023 NF023 NF-023 NF 023 hexasodium NF 023 hexasodium Inhibitor inhibitor inhibit