Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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サンプルについてお問い合わせ | |||||
5 mg | 在庫あり | ¥ 15,000 | |||
10 mg | 在庫あり | ¥ 28,000 | |||
25 mg | 在庫あり | ¥ 60,500 | |||
50 mg | 在庫あり | ¥ 102,500 | |||
100 mg | 在庫あり | ¥ 151,500 | |||
500 mg | 在庫あり | ¥ 319,000 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 16,000 |
説明 | NSC 370284 is a small molecule that directly binds to and inhibits STAT3/5, significantly and selectively suppresses the viability of AML cells with high level of TET1 expression both in vitro and in vivo. |
In vitro | NSC-370284 exhibited the most significant effects in inhibiting cell viability of all four TET1-high AML cell lines, whereas showing no significant inhibition on viability of NB4/t(15;17) AML cells [1].The direct binding of STAT3 and STAT5 on the TET1 loci was further validated in MONOMAC-6 cells, and such binding could be disturbed by NSC-370284 treatmen [1].Analysis suggested a potential direct binding of NSC-370284 to the conserved DNA-binding domain (DBD) of STAT3 or STAT5 [1]. |
In vivo | NSC 370284 treatments significantly inhibited MLL-AF9-induced AML in secondary bone marrow transplantation (BMT) recipient mice, and 57% (4 out of 7) of the NSC-370284-treated mice were cured, as the pathological morphologies in peripheral blood (PB), BM, spleen, and liver tissues all turned to normal. [1] |
分子量 | 387.43 |
分子式 | C21H25NO6 |
CAS No. | 116409-29-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 55 mg/mL (141.96 mM)
You can also refer to dose conversion for different animals. 詳細
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NSC 370284 116409-29-1 JAK/STAT signaling Stem Cells STAT NSC-370284 NSC370284 Inhibitor inhibitor inhibit