Powder: -20°C for 3 years | In solvent: -80°C for 1 year
NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity.
パッケージサイズ | 在庫状況 | 単価(税別) | |||
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1 mg | 在庫あり | ¥ 9,500 | |||
5 mg | 在庫あり | ¥ 22,500 | |||
10 mg | 在庫あり | ¥ 37,500 | |||
25 mg | 在庫あり | ¥ 75,500 | |||
50 mg | 在庫あり | ¥ 121,500 | |||
100 mg | 在庫あり | ¥ 176,500 | |||
1 mL * 10 mM (in DMSO) | 在庫あり | ¥ 27,500 |
説明 | NU6140 is a selective inhibitor of CDK2-cyclin A (IC50, 0.41 μM). It shows 10- to 36-fold selectivity over other CDKs. NU6140 also effectively inhibits Aurora A and Aurora B (IC50s: 67 and 35 nM, respectively). It also enhances the apoptotic effect and has anti-cancer activity. |
ターゲット&IC50 | Aurora A:67 nM, Aurora B:35 nM, CDK5-p25:15 μM, CDK4-CyclinD:5.5 μM, CDK7-CyclinH:3.9 μM, CDK2-CyclinA:0.41 μM, CDK1-CyclinB:6.6 μM |
In vitro | NU6140 enhances catalytic activity of capase-9 and capase-3, causes an increase in the sub-G1 apoptotic cell population. NU6140 is less active on CDK1-cyclin B, CDK4-cyclin D, CDK5-p25 and CDK7-cyclin H (IC50s: 6.6, 5.5, 15 and 3.9 μM, respectively)[1]. |
分子量 | 422.52 |
分子式 | C23H30N6O2 |
CAS No. | 444723-13-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 250 mg/mL (591.69 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. 詳細
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
NU6140 444723-13-1 Cell Cycle/Checkpoint Chromatin/Epigenetic CDK Aurora Kinase Inhibitor inhibit NU 6140 NU-6140 Cyclin dependent kinase inhibitor